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James J Bull

Joseph J. & Jeanne M. Lagowski Regents Professor Emeritus in Molecular Bioscience
Department of Integrative Biology, College of Natural Sciences

Joseph J. & Jeanne M. Lagowski Regents Professorship in Molecular Bioscience (Emeritus)


Postal Address
AUSTIN, TX 78712

Research Summary:

Evolutionary genetics from the molecular to the phenotypic levels comprises the bulk of my research. Specific topics include the evolution of engineered genomes, microbial drug resistance, and adaptation addressed empirically and theoretically. Experimental systems are developed in which evolution occurs over short time periods in the laboratory; the evolved lines are then analyzed at the molecular genetic level, so that the course of evolution is known with certainty. Research organisms are chiefly bacteriophage, enabling complete genome sequencing. Students are encouraged to initiate their research on a well-defined model system to gain experience and then expand their research to problems of their own design.

2010 Springman R, Keller T, Molineux IJ, Bull JJ, Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7, Genetics 184(1): 221-32

2010 Bull JJ, Vimr ER, Molineux IJ., A tale of tails: Sialidase is key to success in a model of phage therapy against K1-capsulated Escherichia coli., Virology 398(1): 79-86

2009 Keller TE, Molineux IJ, Bull JJ, Viral resistance evolution fully escapes a rationally designed lethal inhibitor, Molecular Biology and Evolution 26(9): 2041-6

2008 Bull JJ, Molineux IJ, Predicting evolution from genomics: experimental evolution of bacteriophage T7, Heredity 100(5): 453-63

2008 Bull JJ, Wilke CO, Lethal mutagenesis of bacteria, Genetics 180(2): 1061-70